The purpose of the microfluidic device that is being created is selective detection of the molecules with a specific biochemical interaction in an analytical medium using combination ligand agglutination and micro electrochemical detection. Suggested microelectromechanical detection platform and devices having micromembrane structure are Capacitive Micromachined Ultrasonic Transducers (CMUT). These types of devices feature a mass alteration detection potential which is enough for a biochemical interaction to set. Detection method is basically different from earlier created ones because here for the specific molecule to track it is used not a detector with a modified surface but a special construction having microfluidic device with integrated CMUT. Comparing with the resonance detection principle used in the other types of sensors, this suggested method is better because instead of one informative CMUT parameter – resonance frequency, it uses a two-dimensional or multi-dimensional CMUT space of complex electromechanical impedance. The detectable molecule could be DNA, protein or any other molecule with the exception that microparticles are functionalized with the proper interaction partner. Suggested technique provides an opportunity to perform detection in real time, in liquid medium and without using expensive electronical or optical devices that makes detection process cheaper and faster.
Project funding:
KTU R&D&I Fund
Project results:
Report. Article in a periodical scientific publication, which has a citation index. Project results are presented at the international conference.
Period of project implementation: 2018-04-03 - 2018-12-31
